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KMID : 1037120170350010028
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The World Journal of Men′s Health
2017 Volume.35 No. 1 p.28 ~ p.33
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Clinicopathologic Characteristics and Treatment Outcomes of Penile Cancer
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Nam Jong-Kil
Lee Dong-Hoon
Park Sung-Woo
Kam Sung-Chul
Lee Ki-Soo
Kim Tae-Hyo
Kim Taek-Sang
Oh Cheol-Kyu
Park Hyun-Jun
Kim Tae-Nam
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Abstract
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Purpose: The aim of this study was to assess the clinicopathologic characteristics of penile cancer, including patterns of therapy, oncologic results, and survival.
Materials and Methods: Between January 2005 and July 2015, 71 patients at 6 institutions who had undergone penectomy or penile biopsy were enrolled. Their medical records were reviewed to identify the mode of therapy, pathology reports, and cancer-specific survival (CSS) rate.
Results: Clinicopathologic and outcome information was available for 52 male patients (mean age, 64.3 years; mean follow-up, 61.4 months). At presentation, 17 patients were node-positive, and 4 had metastatic disease. Management was partial penectomy in 34 patients, total penectomy in 12 patients, and chemotherapy or radiotherapy in 6 patients. The pathology reports were squamous cell carcinoma in 50 patients and other types of carcinoma in the remaining 2 patients. Kaplan-Meier survival analysis showed a 5-year CSS rate of 84.0%. In univariate and multivariate analyses, the American Joint Committee on Cancer (AJCC) stage and pathologic grade were associated with survival.
Conclusions: Partial penectomy was the most common treatment of penile lesions. The oncologic outcomes were good, with a 5-year CSS of 84.0%. The AJCC stage and pathologic grade were independent prognostic factors for survival.
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KEYWORD
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Penile neoplasms, Prognosis, Treatment outcome
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